What if work was something you did, rather than somewhere you went? In today's Blackberry-filled, laptop-laden, 24/7 global corporation, that's entirely possible. And some companies, including Best Buy, are realizing it's not only possible, but profitable, as truly flexible schedules, rather than structured flextime arrangements, give way to greater productivity. But radically altering the boundaries between work and life takes the right culture, the right metrics, and open minds. BusinessWeek Management Editor Jena McGregor speaks with Cali Ressler and Jody Thompson, whose consulting firm, CultureRX, plans to help companies make the shift to a new way of working