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JULY 9, 2001

COVER STORY/Online Extra

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Current Clinical Trials of IMC-C225

Note: ImClone (IMCL ) also plans to start a clinical trial for ovarian cancer later this year as well as more colon and pancreatic trials
Patient                            Treatment                Status
Population                         Regimen


Patients with colon IMC-C225 + irinotecan Closed cancer who have failed other treatments



Patients with locally, IMC-C225 + cisplatin Closed newly diagnosed or and radiation recurrent head and neck cancer



Patients with newly IMC-C225 + gemcitabine Closed diagnosed metastatic pancreatic cancer



Patients with recurrent IMC-C226 + cisplatin Enrolling or metastatic head and + 5FU or Taxol patients neck cancer



Patients with chemotherapy- IMC-C225 + carboplatin Enrolling nave stage IV non-small- + paclitaxel patients cell lung cancer



Patients with newly IMC-C225 + irinotecan Enrolling diagnosed stage + leucovorin + 5-FU patients IV colon cancer



Patients with colon IMC-C225 Closed cancer that have failed other treatments



Patients with IMC-C225 + carboplatin Enrolling chemotherapy-nave + gemcitabine patients stage IV non-small- cell lung cancer



Patients with recurrent or IMC-C225 + docetaxel Enrolling progressive non-small-cell patients lung cancer



Patients with newly IMC-C225 + cisplatin or Enrolling diagnosed head and IMC-C225 + placebo patients neck cancer with extensive incurable local-regional disease and distant metastases or local-regional recurrence/persistence or distant metastases after initial treatment with surgery or radiation



Patients with locally IMC-C225 + radiation Enrolling advanced head and neck patients cancer

For more information on clinical trials, contact ImClone at clinicaltrials@imclone.com or at its toll-free hot line, 877 925-6631




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