NEW YORK (AP) — Shares of some top biotechnology companies were mixed at the close of trading:

Amgen Inc. fell $.11 or .1 percent, to $83.94.

Biogen Idec rose $.35 or .2 percent, to $151.95.

Celgene Corp. rose $.04 or .1 percent, to $73.62.

Gilead Sciences Inc. fell $.35 or .6 percent, to $59.31.