BUSINESSWEEK ONLINE : JULY 12, 1999 ISSUE
COVER STORY

Growing Arteries


One of the most exciting frontiers in gene therapy is in the treatment of heart disease. Dr. Ronald G. Crystal of Cornell University's Weill Medical College in New York is one of several researchers who have devised an alternative to bypass surgery or angioplasty. Crystal's version of the therapy uses an engineered adenovirus with a gene that promotes blood-vessel growth. When the virus is injected into a patient near blocked coronary arteries, it can trigger the growth of new arteries--a kind of ''bio-bypass'' around the clogged vessels. Early results are encouraging, but it will be at least two years before tests are completed, Crystal said. The trials are being run by GenVec Inc. of Rockville, Md., with Parke-Davis Pharmaceutical Research, a division of Warner-Lambert Co.



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